MILDRONATE (MELDONIUM) BUY ONLINE

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Buy Meldonium (Mildronate) Online: Exploring the Pharmaceutical Advancements

Meldonium, commercially known as Mildronate®, stands as a pharmaceutical product that emerged in the 1970s, initially developed as an anti-ischemia medication. Over time, its applications have evolved, and it is now recognized as a potent nootropic agent, targeting the restoration of energy and performance in individuals experiencing physical and mental overload. Notably, athletes have embraced Meldonium for its potential to enhance sports performance, making it an intriguing subject in the realm of sports medicine.

Unraveling Meldonium’s Chemical Identity

At its core, Meldonium boasts a diverse chemical composition, encompassing Meldonium dihydrate alongside a combination of elements such as 3-(2,2,2-trimethylhydrazine)propionate, THP, MET-8, and Quaterine. This composition culminates in two available forms: 40 pills of 250mg and 60 pills of 500mg. The administration options encompass white gelatin capsules, harboring a white crystalline powder, or a colorless solution contained within vials.

Decoding the Pharmacological Potential of Meldonium

The key to Meldonium’s profound effects lies in its ability to hinder the accumulation of activated forms of unoxidized fatty acids in cellular environments, ultimately bringing about a normalization of myocardial metabolism. The pharmaceutical’s touted mechanism of action revolves around its role in reestablishing the delicate balance between oxygen delivery and consumption within cells, coupled with its activation of glycolysis, a process functioning efficiently without additional oxygen demands. These combined actions contribute to a reduction in oxidative stress and cellular damage while facilitating a more efficient energy utilization process within the body.

Unveiling the Plethora of Benefits and Effects

Mildronate, with its diverse mechanism of action, engenders a multitude of beneficial effects, rendering it a versatile therapeutic option. Among the key benefits observed are:

  • Increased Efficiency and Improved Mood: Through its influence on energy regulation and cellular metabolism, Meldonium offers users heightened efficiency and improved mood, potentially serving as an asset during times of mental and physical challenges.
  • Mitigating Symptoms of Mental and Physical Overload: Meldonium’s potential to attenuate symptoms associated with mental and physical exhaustion holds great promise in offering respite during taxing periods.
  • Activation of Tissue and Humoral Immunity: An immune-boosting effect is another feather in Meldonium’s cap, as it can activate tissue and humoral immunity, bolstering the body’s defenses.
  • Cardioprotective Effect: Meldonium’s interventions extend to the realm of cardiovascular health, with benefits encompassing the slowing down of necrotic zone formation during acute ischemic myocardial damage, shortening the rehabilitation period, enhancing myocardial contractility, increasing exercise tolerance, and reducing the frequency of angina attacks in heart failure.
  • Enhancing Cerebral Circulation: Individuals grappling with acute and chronic ischemic disorders of cerebral circulation can find solace in Meldonium, which aims to enhance blood circulation in ischemic areas while promoting blood redistribution in favor of affected tissues.
  • Tonic Effect on the Central Nervous System: Beyond physical benefits, Meldonium’s influence extends to the central nervous system, addressing functional disorders of the somatic and autonomic nervous systems, thereby offering potential relief to patients dealing with chronic alcoholism and withdrawal syndrome.

Navigating the Online Realm for Mildronate

In the digital age, convenience reigns supreme, and procuring Mildronate online presents an enticing prospect. Various reputable vendors offer the pharmaceutical in diverse forms, encompassing Mildronate powder, capsules, and vials. However, prudent consumers must exercise due diligence and conduct meticulous research to ensure the acquisition of a genuine and high-quality nootropic supplement.

Among the trusted purveyors in this domain is Extrapharma, renowned for its commitment to providing authentic and unadulterated nootropic products, backed by a substantial body of research and clinical trials. Extrapharma medonium’s offerings include Mildronate in packs of 40x250mg and 60x500mg pills, as well as Mildronate (meldonium) in ampules for injections.

Legal Aspects Surrounding Meldonium

As a pharmaceutical compound officially manufactured in Latvia, Mildronate holds the status of a prescription drug in certain regions, such as Russia, Ukraine, and Baltic countries. Notably, its use is not sanctioned by the Food and Drug Administration (FDA) in the United States, and it lacks authorization in the rest of Europe, which restricts doctors in these regions from prescribing Mildronate. Nonetheless, individuals keen on exploring the potential of Mildronate for personal use can readily access it through reputable online platforms.

Expanding the Scope of Meldonium’s Application

Beyond its acclaim among athletes, Meldonium extends its beneficial effects to relatively healthy individuals as well. Its capacity to enhance work capacity during periods of physical and mental overload stems from its ability to optimize cellular metabolism and improve blood circulation. Notably, animal tests have demonstrated the potential for increased mobility and extended exercise capacity before the onset of fatigue. Furthermore, Meldonium reveals itself as a guardian against the detrimental effects of stress.

Scrutinizing the Role of Meldonium in Sports

Within the realm of sports, Meldonium takes center stage as a sought-after supplement, courtesy of its ability to enhance recovery rates, endurance, and exercise performance. Its purported impact on muscle tissue oxygenation and functionality enhances muscle performance, granting athletes a competitive edge. However, athletes must tread with caution, as Meldonium falls under the classification of an S4 substance as per the World Anti-Doping Agency (WADA) code, specifically encompassing hormone and metabolic modulators. Consequently, its use before serious competitions is ill-advised due to the potential for positive results in doping control tests.


“Athletes have to work very, very close to this border of the physical capacity of the human body, if they cross this border, there is no way back. Their hearts are damaged, their muscles are damaged, etc.”


 – Ivars Kalvins, inventor of meldonium

F.A.Q. related to Mildronate (Meldonium)

  1. What is Mildronate?  Mildronate, also known by its trade name Mildronate®, is a pharmaceutical product that was developed in the 1970s as an anti-ischemia medication. It is a synthetic analog of gamma-butyrobetaine, a compound found in every cell of the human body. The active ingredient in Mildronate is Meldonium dihydrate.
  2. Is Mildronate Safe? Mildronate is generally considered safe when used as directed and under the supervision of a healthcare professional. However, like any medication, it may have potential side effects and interactions with other drugs. It is essential to consult with a qualified healthcare provider before using Mildronate, especially if you have any underlying health conditions or are taking other medications.
  3. How to Test for Mildronate? Testing for Mildronate typically involves specialized laboratory methods, such as mass spectrometry or liquid chromatography. This testing is commonly used in sports anti-doping control to detect prohibited substances, including Meldonium. Athletes should be aware that the World Anti-Doping Agency (WADA) has classified Meldonium as an S4 substance, and its use is banned in competitive sports.
  4. What is Mildronate Used For? Mildronate has a wide range of potential applications. It is known to restore energy and improve performance, making it a popular choice among athletes seeking better sports results. Moreover, Mildronate is used as a nootropic to enhance cognitive function and mental clarity, particularly during periods of physical and mental overload. Additionally, it has cardioprotective effects, improves exercise tolerance, and may be beneficial for certain ischemic conditions.
  5. How to Take Mildronate? The dosage of Mildronate depends on the purpose of use. For increasing tolerance to mental and physical overload, the recommended dosage is typically 250 mg of Mildronate taken 2–4 times per day. Athletes preparing for events may take 500–1000 mg before workouts, preferably in the morning. However, it is crucial to follow the specific dosage instructions provided by a healthcare professional.
  6. How Long Before Feeling Mildronate Effects? The time it takes to feel the effects of Mildronate can vary from person to person and depends on individual factors such as metabolism and overall health condition. Some individuals may experience noticeable effects within a few days, while others may require a more extended period of use to notice significant changes.
  7. Where to Buy Meldonium Mildronate? Mildronate (Meldonium) can be purchased online from reputable vendors. It is essential to ensure that you are buying from a reliable source to obtain a genuine and high-quality product. Always do thorough research and choose vendors with a proven track record in providing authentic pharmaceuticals.Remember, before using Mildronate or any medication, it is best to consult a healthcare professional to determine if it is suitable for your specific health needs and to ensure safe usage.

What is the Effect of Meldonium (Mildronate) in Cellular Function? 

Check out this video explanation on the cellular effects of Mildronate:

Form

ampules, capsules

Dosage

250mg 40 capsules, 500mg 60 capsules, 500mg 90 capsules, 5ml 10 ampules, 5ml 20 ampules, 5ml 5 ampules

Dosage of Mildronate (meldonium)

Understanding Optimal Mildronate Dosages

For individuals seeking to increase their tolerance to mental and physical overload, the recommended dosage of Mildronate stands at 250 mg, administered 2–4 times per day. On the other hand, athletes preparing for upcoming events are encouraged to take a dosage of 500–1000 mg prior to workouts, preferably in the morning. Standard course durations typically span between 14 and 21 days, though individual needs and circumstances may warrant adjustments.

Dosage Scenario Recommended Dosage Frequency Preferred Time of Intake Course Duration
Increase tolerance to mental and physical overload 250 mg 2–4 times per day Throughout the day 14-21 days
Before and during athletic events 500–1000 mg Prior to workouts Morning – (Varies per event)

Please note that the course duration for “Before and during athletic events” can vary based on individual requirements and specific athletic events. It is advisable to consult with a healthcare professional or sports expert for personalized recommendations.

Evaluating Mildronate’s Tolerance Profile

As a pharmaceutical product, Mildronate is generally well-tolerated, with side effects being a rare occurrence. Adverse reactions may include headaches, high blood pressure, agitation, and allergic responses. However, individuals with kidney or liver disorders must exercise caution and consult healthcare professionals before considering the use of this medication.

In summation, Meldonium (Mildronate) emerges as a fascinating pharmaceutical marvel, encapsulating its journey from anti-ischemia medication to a multifaceted nootropic, renowned for its potential to restore energy and optimize performance. From athletes striving for sporting excellence to individuals seeking enhanced productivity and wellbeing, the allure of Meldonium extends far and wide. It is imperative to adhere to recommended dosages, consult with healthcare professionals, and exercise caution while navigating the domains of sports and online pharmaceutical procurement, to ensure safe and effective utilization of this pharmaceutical wonder.

Mildronate for sale: Even if a prescription is not required, it is assumed that you have a valid prescription or doctor’s recommendation. Please do not self-cure. Get expert advice before purchasing Mildronate (meldonium) online.

The drug images are for illustrative purposes only and may differ from the actual product.

The product is intended for the Russian market and can be labeled in Russian (Packaging design may vary). To make sure that you are buying the right product, just translate the word Милдронат into English using Google Translate. Just copy it and paste.

MILDRONATE (MELDONIUM) OFFICIAL INSTRUCTIONS – Capsules

MILDRONATE (MELDONIUM) OFFICIAL INSTRUCTIONS – Injections

Meldonium research

Sources

  1. Mildronate: Mechanisms of action and prospects for correction of pathologic states. Zh. V. Shutenko, D. V. Meirena, T. I. Kagan, N. I. S’yakste & I. Ya. Kalvin’sh. https://link.springer.com/article/10.1007/BF02219376 
  2. Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19. Reinis Vilskersts, Dana Kigitovica, Stanislava Korzh, Melita Videja, Karlis Vilks, Helena Cirule, Andris Skride, Marina Makrecka-Kuka, Edgars Liepinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/35008470/

  3. Carnitine transport into muscular cells. Inhibition of transport and cell growth by mildronate. B Georges, F Le Borgne, S Galland, M Isoir, D Ecosse, F Grand-Jean, J Demarquoy. https://pubmed.ncbi.nlm.nih.gov/10751544/ 

  4. Hyperpolarized magnetic resonance shows that the anti-ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post-ischemic function in the diabetic heart. Dragana Savic, Vicky Ball, Lorenz Holzner, David Hauton, Kerstin N Timm, M Kate Curtis, Lisa C Heather, Damian J Tyler. https://pubmed.ncbi.nlm.nih.gov/33458907/ 

  5. Mildronate: cardioprotective action through carnitine-lowering effect. Maija Dambrova, Edgars Liepinsh, Ivars Kalvinsh. https://pubmed.ncbi.nlm.nih.gov/12242052/

  6. Mildronate protects heart mtDNA from oxidative stress toxicity induced by exhaustive physical exercise. Artem P Gureev, Irina S Sadovnikova, Ekaterina A Shaforostova, Anatoly A Starkov, Vasily N Popov. https://pubmed.ncbi.nlm.nih.gov/33930377/ 

  7. Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate. Nikolajs Sjakste, Andrei L Kleschyov, Jean-Luc Boucher, Larisa Baumane, Maija Dzintare, Dainuvite Meirena, Jelizaveta Sjakste, Karsten Sydow, Thomas Münzel, Ivars Kalvinsh. https://pubmed.ncbi.nlm.nih.gov/15219822/ 

  8. Meldonium improves Huntington’s disease mitochondrial dysfunction by restoring peroxisome proliferator-activated receptor γ coactivator 1α expression. Francesca Di Cristo, Mauro Finicelli, Filomena Anna Digilio, Simona Paladino, Anna Valentino, Filippo Scialò, Maria D’Apolito, Carmela Saturnino, Umberto Galderisi, Antonio Giordano, Mariarosa Anna Beatrice Melone, Gianfranco Peluso. https://pubmed.ncbi.nlm.nih.gov/30362565/ 

  9. Mildronate: an antiischemic drug for neurological indications. Nikolajs Sjakste, Aleksandrs Gutcaits, Ivars Kalvinsh. https://pubmed.ncbi.nlm.nih.gov/16007237/ 

  10. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Wolfgang Schobersberger, Tobias Dünnwald, Günther Gmeiner, Cornelia Blank. https://pubmed.ncbi.nlm.nih.gov/27465696/ 

  11. Carnitine depletion in rat pups from mothers given mildronate: a model of carnitine deficiency in late fetal and neonatal life. Alessandro Peschechera, Maurizio Scalibastri, Francesco Russo, Mauro Giorgio Giarrizzo, Paolo Carminati, Fabio Giannessi, Arduino Arduini, Rita Ricciolini. https://pubmed.ncbi.nlm.nih.gov/15979102/ 

  12. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Maija Dambrova, Marina Makrecka-Kuka, Reinis Vilskersts, Elina Makarova, Janis Kuka, Edgars Liepinsh. https://pubmed.ncbi.nlm.nih.gov/26850121/ 

  13. Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction. Edgars Liepinsh, Reinis Vilskersts, Dagnija Loca, Olga Kirjanova, Osvalds Pugovichs, Ivars Kalvinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/17204911/ 

  14. Single- and Multiple-dose Pharmacokinetic, Safety and Tolerability Study of Mildronate Injection in Healthy Chinese Subjects Pharmacokinetic of Mildronate Injection. Z Zhao, J Chen, W Peng, X Wang, Z Chen, H Tang, Y Liang, Z Ma, J Chen, X Chen, G Zhong, M Huang. https://pubmed.ncbi.nlm.nih.gov/26697890/ 

  15. Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics. Casilde Sesti, Boris Z Simkhovich, Ivars Kalvinsh, Robert A Kloner. https://pubmed.ncbi.nlm.nih.gov/16633095/ 

  16. Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats. Ulrika Beitnere, Zane Dzirkale, Sergejs Isajevs, Juris Rumaks, Simons Svirskis, Vija Klusa. https://pubmed.ncbi.nlm.nih.gov/25446926/ 

  17. Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart. Edgars Liepinsh, Reinis Vilskersts, Elina Skapare, Baiba Svalbe, Janis Kuka, Helena Cirule, Osvalds Pugovics, Ivars Kalvinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/18801379/ 

  18. Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats. Vija Klusa, Ruta Muceniece, Sergejs Isajevs, Darja Isajeva, Ulrika Beitnere, Ilona Mandrika, Jolanta Pupure, Juris Rumaks, Baiba Jansone, Ivars Kalvinsh, Harry V Vinters. https://pubmed.ncbi.nlm.nih.gov/23537732/ 

  19. Mildronate improves carotid baroreceptor reflex function in patients with chronic heart failure. Andris Vitols, Daina Voita, Vilnis Dzerve. https://www.researchgate.net/publication/228500027_Mildronate_improves_carotid_baroreceptor_reflex_function_in_patients_with_chronic_heart_failure 

  20. Mildronate and its neuroregulatory mechanisms: targeting the mitochondria, neuroinflammation, and protein expression. Vija Klusa, Ulrika Beitnere, Jolanta Pupure, Sergejs Isajevs, Juris Rumaks, Simons Svirskis, Zane Dzirkale, Ivars Kalvinsh. https://pubmed.ncbi.nlm.nih.gov/24375241/ 

  21. Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats. Edgars Liepinsh, Reinis Vilskersts, Liga Zvejniece, Baiba Svalbe, Elina Skapare, Janis Kuka, Helena Cirule, Solveiga Grinberga, Ivars Kalvinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/19594753/ 

  22. Efficacy and safety of mildronate for acute ischemic stroke: a randomized, double-blind, active-controlled phase II multicenter trial. Yi Zhu, Guangyun Zhang, Jun Zhao, Deshuai Li, Xiaodong Yan, Juanfang Liu, Xuedong Liu, Haibo Zhao, Jielai Xia, Xiao Zhang, Zhengyi Li, Baorong Zhang, Zongcheng Guo, Lianyuan Feng, Zhaodong Zhang, Fang Qu, Gang Zhao. https://pubmed.ncbi.nlm.nih.gov/23949899/ 

  23. Effects of long-term mildronate treatment on cardiac and liver functions in rats. Edgars Liepinsh, Janis Kuka, Baiba Svalbe, Reinis Vilskersts, Elina Skapare, Helena Cirule, Osvalds Pugovics, Ivars Kalvinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/19663820/ 
  24. A dose-dependent improvement in exercise tolerance in patients with stable angina treated with mildronate: a clinical trial “MILSS I”. Vilnis Dzerve; MILSS I Study Group. https://pubmed.ncbi.nlm.nih.gov/22186118/ 

  25. Effects of ischemia-reperfusion and pretreatment with mildronate on rat liver mitochondrial function. Sonata Trumbeckaite, Marius Kincius, Andrius Preidis, Monika Preidiene, Vincentas Veikutis, Vilmante Borutaite, Antanas Gulbinas. https://pubmed.ncbi.nlm.nih.gov/19904009/ 

  26. Mildronate as a regulator of protein expression in a rat model of Parkinson’s disease. Sergejs Isajevs, Darja Isajeva, Ulrika Beitnere, Baiba Jansone, Ivars Kalvinsh, Vija Klusa. https://pubmed.ncbi.nlm.nih.gov/22186119/ 

  27. Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice. Reinis Vilskersts, Edgars Liepinsh, Lukasz Mateuszuk, Solveiga Grinberga, Ivars Kalvinsh, Stefan Chlopicki, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/19325254/ 

  28. The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine. Janis Kuka, Reinis Vilskersts, Helena Cirule, Marina Makrecka, Osvalds Pugovics, Ivars Kalvinsh, Maija Dambrova, Edgars Liepinsh. https://pubmed.ncbi.nlm.nih.gov/21903968/ 

  29. Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism. Kristaps Jaudzems, Janis Kuka, Aleksandrs Gutsaits, Kirils Zinovjevs, Ivars Kalvinsh, Edgars Liepinsh, Edvards Liepinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/19912061/

  30. Mildronate exerts acute anticonvulsant and antihypnotic effects. Liga Zvejniece, Baiba Svalbe, Marina Makrecka, Edgars Liepinsh, Ivars Kalvinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/20661137/

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