Mildronate 500mg 60 capsules

MILDRONATE® (MELDONIUM)

$25,00 – $65,00

BUY MELDONIUM (MILDRONATE®) ONLINE

Mildronate® (Meldonium) is available as capsules and injectable solution. The drug acts as a metabolic enhancer in cells. Mildronate® improves how the body produces and uses energy. Meldonium changes how cells process fats for fuel. The drug protects heart muscle during stress periods. Effects begin quickly after administration. Clinical studies show significant endurance improvement. The medicine speeds up recovery processes. Results become noticeable within several days. The drug proves most effective for heart conditions.

Basic Definition:
Meldonium is a medication originally created to treat heart problems. It goes by the trade name Mildronate®. This drug was first made in the 1970s in Latvia. It started as a heart medication but found new uses over time.
Key Features:
The drug comes in two simple forms. Users can choose between 250mg or 500mg pills. The smaller dose comes in packs of 40 pills. The larger dose comes in packs of 60 pills. Each pill contains a white powder inside a clear capsule. Some versions come as a clear liquid in small glass bottles.
How It Works:
The drug helps cells use energy better. Think of it like a traffic controller for cell energy. It stops harmful fats from building up in cells. This protection is especially important for heart cells. The drug helps balance oxygen use, similar to how a thermostat controls temperature.
Energy Benefits:
The main benefit is better energy use in the body. Athletes notice they can exercise longer. Regular users report better mental focus. The drug helps both body and mind work more efficiently. This dual action makes it popular among busy professionals and athletes.
Protective Effects:
Meldonium acts like a shield for heart cells. It helps protect the brain’s blood flow. The drug strengthens the body’s natural defenses. Users often report fewer effects from physical stress. Mental fatigue becomes less noticeable.
Safety and Testing:
Scientists test for Meldonium using special lab equipment. The tests look for specific chemical signatures. These tests are similar to other drug tests. Athletes should know that sports organizations ban this drug. The World Anti-Doping Agency classifies it as a performance enhancer.
Usage Guidelines:
A typical starting dose is 250 mg twice daily. Some people take it up to four times per day. Athletes sometimes use higher doses of 500-1000 mg. These doses are taken before morning workouts. Effects usually appear within the first week.
Legal Status:
Different countries have different rules. Latvia makes the drug legally. Russia requires a prescription. The United States hasn’t approved it for use. Most European countries don’t allow doctors to prescribe it. Online purchases remain possible in many places.
Research Support:
Laboratory studies show clear benefits. Animals in tests could exercise longer. Their stress resistance improved. Human studies confirm these findings. The results show both physical and mental improvements.
Recommendations:
New users should start with the lowest dose. Medical supervision helps ensure safety. Regular check-ups can catch any problems early. Users should track their response to the drug. Side effects, though rare, need monitoring.

What is the Effect of Meldonium (Mildronate) in Cellular Function? 

Check out this video explanation on the cellular effects of Mildronate:

 

MILDRONATE (MELDONIUM) FOR INJECTIONS OFFICIAL INSTRUCTIONS

MILDRONATE (MELDONIUM) CAPSULES OFFICIAL INSTRUCTIONS

Form

ampules, capsules
Dosage

250mg 40 capsules, 500mg 60 capsules, 500mg 90 capsules, 5ml 10 ampules, 5ml 20 ampules, 5ml 5 ampules

Dosage of Mildronate (meldonium)

Understanding Optimal Mildronate Dosages

For individuals seeking to increase their tolerance to mental and physical overload, the recommended dosage of Mildronate stands at 250 mg, administered 2–4 times per day. On the other hand, athletes preparing for upcoming events are encouraged to take a dosage of 500–1000 mg prior to workouts, preferably in the morning. Standard course durations typically span between 14 and 21 days, though individual needs and circumstances may warrant adjustments.

Dosage Scenario Recommended Dosage Frequency Preferred Time of Intake Course Duration
Increase tolerance to mental and physical overload 250 mg 2–4 times per day Throughout the day 14-21 days
Before and during athletic events 500–1000 mg Prior to workouts Morning – (Varies per event)

Please note that the course duration for “Before and during athletic events” can vary based on individual requirements and specific athletic events. It is advisable to consult with a healthcare professional or sports expert for personalized recommendations.

Evaluating Mildronate’s Tolerance Profile

As a pharmaceutical product, Mildronate is generally well-tolerated, with side effects being a rare occurrence. Adverse reactions may include headaches, high blood pressure, agitation, and allergic responses. However, individuals with kidney or liver disorders must exercise caution and consult healthcare professionals before considering the use of this medication.

In summation, Meldonium (Mildronate) emerges as a fascinating pharmaceutical marvel, encapsulating its journey from anti-ischemia medication to a multifaceted nootropic, renowned for its potential to restore energy and optimize performance. From athletes striving for sporting excellence to individuals seeking enhanced productivity and wellbeing, the allure of Meldonium extends far and wide. It is imperative to adhere to recommended dosages, consult with healthcare professionals, and exercise caution while navigating the domains of sports and online pharmaceutical procurement, to ensure safe and effective utilization of this pharmaceutical wonder.

Mildronate for sale: Even if a prescription is not required, it is assumed that you have a valid prescription or doctor’s recommendation. Please do not self-cure. Get expert advice before purchasing Mildronate (meldonium) online.

The drug images are for illustrative purposes only and may differ from the actual product.

The product is intended for the Russian market and can be labeled in Russian (Packaging design may vary). To make sure that you are buying the right product, just translate the word Милдронат into English using Google Translate. Just copy it and paste.

MILDRONATE (MELDONIUM) OFFICIAL INSTRUCTIONS – Capsules

MILDRONATE (MELDONIUM) OFFICIAL INSTRUCTIONS – Injections

Meldonium research

Sources

  1. Mildronate: Mechanisms of action and prospects for correction of pathologic states. Zh. V. Shutenko, D. V. Meirena, T. I. Kagan, N. I. S’yakste & I. Ya. Kalvin’sh. https://link.springer.com/article/10.1007/BF02219376 

  2. Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19. Reinis Vilskersts, Dana Kigitovica, Stanislava Korzh, Melita Videja, Karlis Vilks, Helena Cirule, Andris Skride, Marina Makrecka-Kuka, Edgars Liepinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/35008470/

  3. Carnitine transport into muscular cells. Inhibition of transport and cell growth by mildronate. B Georges, F Le Borgne, S Galland, M Isoir, D Ecosse, F Grand-Jean, J Demarquoy. https://pubmed.ncbi.nlm.nih.gov/10751544/ 

  4. Hyperpolarized magnetic resonance shows that the anti-ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post-ischemic function in the diabetic heart. Dragana Savic, Vicky Ball, Lorenz Holzner, David Hauton, Kerstin N Timm, M Kate Curtis, Lisa C Heather, Damian J Tyler. https://pubmed.ncbi.nlm.nih.gov/33458907/ 

  5. Mildronate: cardioprotective action through carnitine-lowering effect. Maija Dambrova, Edgars Liepinsh, Ivars Kalvinsh. https://pubmed.ncbi.nlm.nih.gov/12242052/

  6. Mildronate protects heart mtDNA from oxidative stress toxicity induced by exhaustive physical exercise. Artem P Gureev, Irina S Sadovnikova, Ekaterina A Shaforostova, Anatoly A Starkov, Vasily N Popov. https://pubmed.ncbi.nlm.nih.gov/33930377/ 

  7. Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate. Nikolajs Sjakste, Andrei L Kleschyov, Jean-Luc Boucher, Larisa Baumane, Maija Dzintare, Dainuvite Meirena, Jelizaveta Sjakste, Karsten Sydow, Thomas Münzel, Ivars Kalvinsh. https://pubmed.ncbi.nlm.nih.gov/15219822/ 

  8. Meldonium improves Huntington’s disease mitochondrial dysfunction by restoring peroxisome proliferator-activated receptor γ coactivator 1α expression. Francesca Di Cristo, Mauro Finicelli, Filomena Anna Digilio, Simona Paladino, Anna Valentino, Filippo Scialò, Maria D’Apolito, Carmela Saturnino, Umberto Galderisi, Antonio Giordano, Mariarosa Anna Beatrice Melone, Gianfranco Peluso. https://pubmed.ncbi.nlm.nih.gov/30362565/ 

  9. Mildronate: an antiischemic drug for neurological indications. Nikolajs Sjakste, Aleksandrs Gutcaits, Ivars Kalvinsh. https://pubmed.ncbi.nlm.nih.gov/16007237/ 

  10. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Wolfgang Schobersberger, Tobias Dünnwald, Günther Gmeiner, Cornelia Blank. https://pubmed.ncbi.nlm.nih.gov/27465696/ 

  11. Carnitine depletion in rat pups from mothers given mildronate: a model of carnitine deficiency in late fetal and neonatal life. Alessandro Peschechera, Maurizio Scalibastri, Francesco Russo, Mauro Giorgio Giarrizzo, Paolo Carminati, Fabio Giannessi, Arduino Arduini, Rita Ricciolini. https://pubmed.ncbi.nlm.nih.gov/15979102/ 

  12. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Maija Dambrova, Marina Makrecka-Kuka, Reinis Vilskersts, Elina Makarova, Janis Kuka, Edgars Liepinsh. https://pubmed.ncbi.nlm.nih.gov/26850121/ 

  13. Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction. Edgars Liepinsh, Reinis Vilskersts, Dagnija Loca, Olga Kirjanova, Osvalds Pugovichs, Ivars Kalvinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/17204911/ 

  14. Single- and Multiple-dose Pharmacokinetic, Safety and Tolerability Study of Mildronate Injection in Healthy Chinese Subjects Pharmacokinetic of Mildronate Injection. Z Zhao, J Chen, W Peng, X Wang, Z Chen, H Tang, Y Liang, Z Ma, J Chen, X Chen, G Zhong, M Huang. https://pubmed.ncbi.nlm.nih.gov/26697890/ 

  15. Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics. Casilde Sesti, Boris Z Simkhovich, Ivars Kalvinsh, Robert A Kloner. https://pubmed.ncbi.nlm.nih.gov/16633095/ 

  16. Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats. Ulrika Beitnere, Zane Dzirkale, Sergejs Isajevs, Juris Rumaks, Simons Svirskis, Vija Klusa. https://pubmed.ncbi.nlm.nih.gov/25446926/ 

  17. Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart. Edgars Liepinsh, Reinis Vilskersts, Elina Skapare, Baiba Svalbe, Janis Kuka, Helena Cirule, Osvalds Pugovics, Ivars Kalvinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/18801379/ 

  18. Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats. Vija Klusa, Ruta Muceniece, Sergejs Isajevs, Darja Isajeva, Ulrika Beitnere, Ilona Mandrika, Jolanta Pupure, Juris Rumaks, Baiba Jansone, Ivars Kalvinsh, Harry V Vinters. https://pubmed.ncbi.nlm.nih.gov/23537732/ 

  19. Mildronate improves carotid baroreceptor reflex function in patients with chronic heart failure. Andris Vitols, Daina Voita, Vilnis Dzerve. https://www.researchgate.net/publication/228500027_Mildronate_improves_carotid_baroreceptor_reflex_function_in_patients_with_chronic_heart_failure 

  20. Mildronate and its neuroregulatory mechanisms: targeting the mitochondria, neuroinflammation, and protein expression. Vija Klusa, Ulrika Beitnere, Jolanta Pupure, Sergejs Isajevs, Juris Rumaks, Simons Svirskis, Zane Dzirkale, Ivars Kalvinsh. https://pubmed.ncbi.nlm.nih.gov/24375241/ 

  21. Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats. Edgars Liepinsh, Reinis Vilskersts, Liga Zvejniece, Baiba Svalbe, Elina Skapare, Janis Kuka, Helena Cirule, Solveiga Grinberga, Ivars Kalvinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/19594753/ 

  22. Efficacy and safety of mildronate for acute ischemic stroke: a randomized, double-blind, active-controlled phase II multicenter trial. Yi Zhu, Guangyun Zhang, Jun Zhao, Deshuai Li, Xiaodong Yan, Juanfang Liu, Xuedong Liu, Haibo Zhao, Jielai Xia, Xiao Zhang, Zhengyi Li, Baorong Zhang, Zongcheng Guo, Lianyuan Feng, Zhaodong Zhang, Fang Qu, Gang Zhao. https://pubmed.ncbi.nlm.nih.gov/23949899/ 

  23. Effects of long-term mildronate treatment on cardiac and liver functions in rats. Edgars Liepinsh, Janis Kuka, Baiba Svalbe, Reinis Vilskersts, Elina Skapare, Helena Cirule, Osvalds Pugovics, Ivars Kalvinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/19663820/ 

  24. A dose-dependent improvement in exercise tolerance in patients with stable angina treated with mildronate: a clinical trial “MILSS I”. Vilnis Dzerve; MILSS I Study Group. https://pubmed.ncbi.nlm.nih.gov/22186118/ 

  25. Effects of ischemia-reperfusion and pretreatment with mildronate on rat liver mitochondrial function. Sonata Trumbeckaite, Marius Kincius, Andrius Preidis, Monika Preidiene, Vincentas Veikutis, Vilmante Borutaite, Antanas Gulbinas. https://pubmed.ncbi.nlm.nih.gov/19904009/ 

  26. Mildronate as a regulator of protein expression in a rat model of Parkinson’s disease. Sergejs Isajevs, Darja Isajeva, Ulrika Beitnere, Baiba Jansone, Ivars Kalvinsh, Vija Klusa. https://pubmed.ncbi.nlm.nih.gov/22186119/ 

  27. Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice. Reinis Vilskersts, Edgars Liepinsh, Lukasz Mateuszuk, Solveiga Grinberga, Ivars Kalvinsh, Stefan Chlopicki, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/19325254/ 

  28. The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine. Janis Kuka, Reinis Vilskersts, Helena Cirule, Marina Makrecka, Osvalds Pugovics, Ivars Kalvinsh, Maija Dambrova, Edgars Liepinsh. https://pubmed.ncbi.nlm.nih.gov/21903968/ 

  29. Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism. Kristaps Jaudzems, Janis Kuka, Aleksandrs Gutsaits, Kirils Zinovjevs, Ivars Kalvinsh, Edgars Liepinsh, Edvards Liepinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/19912061/

  30. Mildronate exerts acute anticonvulsant and antihypnotic effects. Liga Zvejniece, Baiba Svalbe, Marina Makrecka, Edgars Liepinsh, Ivars Kalvinsh, Maija Dambrova. https://pubmed.ncbi.nlm.nih.gov/20661137/

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